1-N-isoserylkanamycins and the production thereof

Details 1-N-isoserylkanamycins and the production thereof 1-N-isoserylkanamycins and the production thereof

1974-05-01

1976-02-17

Brown, Johnnie R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424180, C07A 1504

Patent

active

039391434

ABSTRACT:
1-N-isoseryl derivatives of kanamycin A, kanamycin B and 3',4'-dideoxykanamycin B are now synthesized, which are new and useful compounds active against gram-negative and gram-positive bacteria and also against drug-resistant strains of these bacteria. The production of the 1-N-isoserylkanamycins is made by reacting isoserine with the 1-N-amino group of kanamycin with the functional amino group(s) being protected, following by removal of the amino-protecting groups and by chromatographic separation of the desired 1-N-isoserylation product.

REFERENCES:
patent: 3032547 (1962-05-01), Rothrock et al.
patent: 3753973 (1973-08-01), Umezawa et al.
patent: 3781268 (1973-12-01), Kawaguchi et al.
Morrison and Boyd, "Organic Chemistry" Allynl and Bacon Inc., Boston, 1970, p. 1101.

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