1-N-aminohydroxyacyl derivatives of gentamicin B

Details 1-N-aminohydroxyacyl derivatives of gentamicin B 1-N-aminohydroxyacyl derivatives of gentamicin B

1979-04-24

1981-08-11

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, A61K 3171, C07H 1522

Patent

active

042835283

ABSTRACT:
1-N-(R-.beta.-amino-.alpha.-hydroxypropionyl) gentamicin B, 1-N-(R-.gamma.-amino-.alpha.-hydroxybutyryl) gentamicin B, 1-N-(R-.delta.-amino-.alpha.-hydroxyvaleryl) gentamicin B and the corresponding diastereoisomers derived from the respective S-aminohydroxy acids and the acid addition salts thereof exhibit substantial antibacterial activity, especially against strains of bacteria which are resistant to gentamicin B and acid addition salts thereof.

REFERENCES:
patent: 4002742 (1977-01-01), Wright et al.
patent: 4029882 (1977-06-01), Wright
patent: 4104372 (1978-08-01), Umezawa et al.

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