1-N-(.alpha.-hydroxy-.omega.-aminoalkanoyl) derivatives of 3'-de

Details 1-N-(.alpha.-hydroxy-.omega.-aminoalkanoyl) derivatives of 3'-de 1-N-(.alpha.-hydroxy-.omega.-aminoalkanoyl) derivatives of 3'-de

1976-04-20

1978-08-01

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 10, 536 17, A61K 3171, C07H 1522

Patent

active

041043723

ABSTRACT:
1-N-(.alpha.-hydroxy-.omega.-aminoalkanoyl)-derivatives of 3'-deoxykanamycin A or 6'-N-methyl-3'-deoxykanamycin A are provided as new and useful compounds which are active against gram-negative and gram-positive bacteria, including drug-resistant strains of these bacteria. Examples of these compounds include 1-N-((SR)-.beta.-amino-.alpha.-hydroxypropionyl)-3'-deoxykanamycin A, 1-N-((S)-.gamma.-amino-.alpha.-hydroxybutyryl)-3'-deoxykanamycin A, 1-N-((S)-.delta.-amino-.alpha.-hydroxyvaleryl)-3'-deoxykanamycin A and 1-N-((S)-.gamma.-amino-.alpha.-hydroxybutyryl)-6'-N-methyl-3'-deoxykanamyc in A. The compounds may be prepared by selective acylation of the 1-amino group of 3'-deoxykanamycin A or 6'-N-methyl-3'-deoxykanamycin A with a corresponding .alpha.-hydroxy-.omega.-amino-alkanoic acid.

REFERENCES:
patent: 3904597 (1975-09-01), Naito et al.
patent: 3929761 (1975-12-01), Umezawa et al.
patent: 3939143 (1976-02-01), Umezawa et al.

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