1-N-alkyl-aminoglycoside-XK-88 derivatives and methods for their

Details 1-N-alkyl-aminoglycoside-XK-88 derivatives and methods for their 1-N-alkyl-aminoglycoside-XK-88 derivatives and methods for their

1975-11-04

1977-01-11

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

195 80R, 424180, 424181, 536 4, C07H 1522

Patent

active

040026086

ABSTRACT:
1-N-Alkyl-Aminoglycoside-XK-88 derivatives, valuable as antibacterial agents, are prepared by the reaction of an acid addition salt of the corresponding 1-N-unsubstituted-Aminoglycoside-XK-88 antibacterial derivative or of a 2"-N-alkanoyl-Aminoglycoside-XK-88-5 derivative in an inert solvent, preferably a protic solvent containing water, with one equivalent of a hydride-donor reducing agent and with at least one equivalent of an aldehyde.
The 2"-N-alkanoyl-Aminoglycoside-XK-88-5 intermediates are prepared by the reaction of a partially neutralized acid addition salt of Aminoglycoside-XK-88-5 with an acylating agent, and isolating the 2"-N-alkanoyl-Aminoglycoside-XK-88-5.

REFERENCES:
patent: 3350387 (1967-10-01), Vanderhaeghe

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