1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-

Details 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2- 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-

1982-09-07

1984-08-28

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 133, 536 136, 536 166, 424180, C07H 1522

Patent

active

044685122

ABSTRACT:
Zinc salts are used to effect the regio-selective acylation and alkylation of the 1-amino group of 4-O-substituted-2-deoxystreptamine-containing aminoglycosides. The 1-N-substituted derivatives of apramycin, 3'-hydroxyapramycin, certain .alpha. or .beta.-(lower alkyl)aprosaminides and certain .alpha. or .beta.-(substituted lower alkyl)-aprosaminides are new. The 1-N-substituted-4-O-substituted-2-deoxystreptamine aminoglycosides produced by the process of this invention are antibacterial agents.

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