1-Methyltetrazol-5-ylthio ester of cyanomethylthioacetic acid

Details 1-Methyltetrazol-5-ylthio ester of cyanomethylthioacetic acid 1-Methyltetrazol-5-ylthio ester of cyanomethylthioacetic acid

1983-10-25

1984-06-12

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D25704

Patent

active

044543239

ABSTRACT:
Novel thioesters effective as acylating agents for amines or hydrazines, especially effective as active esters in synthesis of cephalosporin compounds are disclosed. The novel thioester of the present invention can be prepared by reacting a thiol or a derivative thereof with an acetic acid derivative or a reactive derivative thereof. By reacting the thioester of the present invention with a 7-aminocephalosporin derivative or a salt thereof, cephalosporin derivatives or pharmacologically acceptable salts thereof which are excellent antibiotic substances having a high antimicrobial activity can be obtained in high yield very safely.

REFERENCES:
patent: 3946003 (1976-03-01), Cooper
patent: 4144391 (1979-03-01), Hatfield
patent: 4258195 (1981-03-01), Shibuya et al.
patent: 4351947 (1982-09-01), Shibuya et al.

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