1-[Methylated piperidino(and pyrrolidin-1-yl)]-3-(substituted ph

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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26029368, 26029369, 26029373, 26029383, 260296R, 2603265D, 2603265S, 2603265SM, 2603265SF, 2603265M, 424263, 424267, 424274, C07D21114

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039547760

ABSTRACT:
1-[Methylated piperidino (and pyrrolidin-1-yl)]-3-(substituted phenoxy)-2-propanols of the formula: ##SPC1##
Wherein R is a 2-thienylmethyl group, a 2-pyridylmethyl group, a 2-pyridyl group, a tetrahydrofurfuryloxy group, a furfuryloxy group, a 2-thienylmethoxy group, a 2-pyridyloxy group or a group of the formula R.sup.5 --X--A--O-- wherein R.sup.5 is a lower alkyl group, X is --O--, --S-- or --SO.sub.2 --, and A is a lower alkylene group or a --CH.sub.2 --C.ident.C--CH.sub.2 -- group, R.sup.1 is a hydrogen atom, a lower alkyl group or a halogen atom, R.sup.2, R.sup.3 and R.sup.4 are each a hydrogen atom or a methyl group, and n is zero or 1, and pharmaceutically acceptable acid addition and quarternary ammonium salts thereof are disclosed. They exhibit antiarrhythmic action, local anaesthetic action, analgesic action and gastric juice secretion inhibiting action.

REFERENCES:
patent: 3723476 (1973-03-01), Nakanishi et al.

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