1-Hydroxymethyl-11,15-dihydroxy-prosten-1-ol-derivatives

Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing

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568367, 568379, 568380, 568631, 568644, 568645, 568660, 568664, 568669, 568670, 568807, 568816, 568822, 568838, 560255, 560231, 560 61, 560 62, 560 64, 560 73, 560106, 560107, 424308, 424311, 424331, 424339, 424340, 424341, 424343, 560 65, 568376, C07C 49597, C07C 3506, C07C 49798

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042886309

ABSTRACT:
Prostaglandin analogs are disclosed that have the .alpha.-chain terminating with the group --CH(OR')OR" wherein R' and R" are the same or different and are hydrogen, C.sub.1 to C.sub.4 alkanoyl or optionally substituted benzoyl, the substituents selected from the group C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, halo and trifluoromethyl. These compounds are useful as hypotensive agents, gastric secretory and platelet aggregation enhibitors and bronchodilators.

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patent: 3950406 (1976-04-01), Floyd et al.
patent: 3965143 (1976-06-01), Collins et al.
patent: 4061670 (1977-12-01), Floyd et al.
patent: 4212969 (1980-07-01), Wissner et al.
Bently, Chem. Soc. Rev., #2, pp. 29-70, (1973).

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