1-(hydroxylaminoalkyl) indole derivatives as inhibitors of leuko

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514418, 548483, 548484, 548485, 548486, 548492, 548495, 548494, 548495, 548510, C07D20908, A61K 31405

Patent

active

051323192

ABSTRACT:
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis and allograft rejection and in preventing the formation of atherosclerotic plaques.

REFERENCES:
patent: 4822809 (1989-04-01), Summers et al.
patent: 4822811 (1989-04-01), Summers

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