1-Hydroxyimidazole-5-methanamine derivatives

Details 1-Hydroxyimidazole-5-methanamine derivatives 1-Hydroxyimidazole-5-methanamine derivatives

1978-11-03

1980-11-04

Randolph, John D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424273R, 546210, 548337, 548342, A61K 31415, A61K 3144, C07D23370, C07D40302

Patent

active

042320291

ABSTRACT:
1-Hydroxyimidazole-5-methanamine derivatives characterized by having a lower alkyl group at positions N, N and 5 of the latter derivatives as well as having various substituents at position 2 of the imidazole ring are disclosed. These derivatives are useful as antihypertensive agents in a mammal. Methods for their preparation, use and pharmaceutical compositions also are disclosed.

REFERENCES:
patent: 3488423 (1970-01-01), Doebel et al.
Franchetti et al., Il Farmaco, Ed. Sci., vol. 27, pp. 46 to 59, (1972).
Chemical Abstracts, Ninth Collective Index, vols. 76-85, of 1972-1976, p. 19367CS.
Chemical Abstracts, vol. 84, Abst. 90447n, (1976), Abst. of Kitaura et al., Bioorganic Chemistry, vol. 4, pp. 327-349, 1975).
Kitaura et al., Bioorganic Chemistry, vol. 4, pp. 327-349, 1975.

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