Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-05-30
2010-10-19
Andres, Janet L (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S268400, C546S269100
Reexamination Certificate
active
07816380
ABSTRACT:
α-Hydroxycycloalkanecarboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, wherein formula (a) is a single or double bond; R1, R2and R3are each independently selected from H, halogen and OH; or R1and R2attached to the same carbon atom together represent oxo; R4is H or methyl; R5is Cl or I2; R6is selected from —CO2—C1-4alkyl, —O—C1-4alkyl, —O—C1-4haloalkyl, 2-methyltetrazol-5-yl, 5-methyl-1,2,4-oxadiazol-3-yl, 3-methyl-1,2,4-oxadiazol-5-yl, 5-halomethyl-1,2,4-oxadiazol-3-yl, 3-halomethyl-1,2,4-oxadiazol-5-yl, tetrazol-5-yl, 5-halomethyl-1,2,3-triazolyl, and 5-methyl-1,2,3-triazolyl; R7and R8are each independently Cl or I2; and n is 0 or 1, are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.
REFERENCES:
patent: 2008/0318976 (2008-12-01), Wood et al.
patent: WO2004/019868 (2004-03-01), None
patent: 2005063690 (2005-07-01), None
patent: WO2005/063690 (2005-07-01), None
Patani et. al., “Bioisosterism: A Rational Approach in Drug Design”, Chem. Rev. 1996, 96, 3147-3176.
Kuduk Scott D.
Wood Michael R.
Andres Janet L
Camara Valerie J.
Merck Sharp & Dohme Corp.
Robinson Binta M
Yang Mollie M.
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