1-hydroxycycloalkanecarboxamide derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C546S268400, C546S269100

Reexamination Certificate

active

07816380

ABSTRACT:
α-Hydroxycycloalkanecarboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, wherein formula (a) is a single or double bond; R1, R2and R3are each independently selected from H, halogen and OH; or R1and R2attached to the same carbon atom together represent oxo; R4is H or methyl; R5is Cl or I2; R6is selected from —CO2—C1-4alkyl, —O—C1-4alkyl, —O—C1-4haloalkyl, 2-methyltetrazol-5-yl, 5-methyl-1,2,4-oxadiazol-3-yl, 3-methyl-1,2,4-oxadiazol-5-yl, 5-halomethyl-1,2,4-oxadiazol-3-yl, 3-halomethyl-1,2,4-oxadiazol-5-yl, tetrazol-5-yl, 5-halomethyl-1,2,3-triazolyl, and 5-methyl-1,2,3-triazolyl; R7and R8are each independently Cl or I2; and n is 0 or 1, are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.

REFERENCES:
patent: 2008/0318976 (2008-12-01), Wood et al.
patent: WO2004/019868 (2004-03-01), None
patent: 2005063690 (2005-07-01), None
patent: WO2005/063690 (2005-07-01), None
Patani et. al., “Bioisosterism: A Rational Approach in Drug Design”, Chem. Rev. 1996, 96, 3147-3176.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

1-hydroxycycloalkanecarboxamide derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 1-hydroxycycloalkanecarboxamide derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1-hydroxycycloalkanecarboxamide derivatives will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4196287

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.