Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-12-29
1994-08-16
Berch, Mark L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544267, A61K 3152, C07D47306
Patent
active
053387414
ABSTRACT:
Compounds, physiologically acceptable salts of the compounds and pharmaceutical compositions containing the compounds or the salts are provided wherein the compounds have a formula of: ##STR1## in which R.sub.1 is a C.sub.2 -C.sub.5 .omega.-hydroxy-n-alkyl group or a C.sub.3 -C.sub.5 (.omega.-1)-hydroxy-n-alkyl group, R.sub.3 is a C.sub.1-C.sub.4 alkyl group, R.sub.8 is H, methyl, or ethyl and the sum of the carbon atoms in R.sub.1 and R.sub.3 is between 4 and 9 and provide inotropic (cardiotonic) activity.
REFERENCES:
patent: 2517410 (1950-08-01), Papesch
patent: 3065234 (1962-11-01), Klingler
patent: 4108995 (1978-08-01), Mohler et al.
patent: 4469698 (1984-09-01), Philippossian et al.
patent: 4515795 (1985-05-01), Hinze et al.
patent: 4548818 (1985-10-01), Kjellin et al.
patent: 4833146 (1989-05-01), Gebert et al.
Erjavec et al, Arch. Int. Pharmacodynamics 155, p. 251 (1965).
Physicians' Desk Reference, Medical Economics Co., Inc., Oradell, N.J., (1988), pp. 1055-1056, 2227-2229.
Cardiovascular Pharmacology, 2nd ed., Antonaccio, ed., Raven Press, New York, 1984, Francis, et al., pp. 295-327.
Martindale, "The Extra Pharmocopeia", 29th ed, Reynolds, ed., The Pharmaceutical Press, London, 1989, Milrinone entry.
The Merck Index, 8th ed., (1968) pp. 60 and 1034.
Hinze, et al., Arzneim.-Forsch. (Drug Res.), vol. 22, No. 7, pp. 1144-1151 (1972).
Hinze, Chemical Abstracts, vol. 78(5):23834z (1972).
Fumeaux Rene
Philippossian Georges
Berch Mark L.
Nestec S.A.
LandOfFree
1-hydroxyalkylxanthines and medicaments containing them does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 1-hydroxyalkylxanthines and medicaments containing them, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1-hydroxyalkylxanthines and medicaments containing them will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-952017