1-Hydroxy-3-amino-alkane-1,1-diphosphonic acids and salts

Details 1-Hydroxy-3-amino-alkane-1,1-diphosphonic acids and salts 1-Hydroxy-3-amino-alkane-1,1-diphosphonic acids and salts

1976-07-16

1977-10-18

Evans, Joseph E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

210 58, 204DIG2, 252 88, 252180, 252DIG11, 252DIG17, 2604381, 26050112, 424 49, 424 54, 424204, C07F 938

Patent

active

040545989

ABSTRACT:
1-Hydroxy-3-amino-alkane-1,1-diphosphonic acids having the formula ##STR1## wherein X is a member selected from the group consisting of ##STR2## and ##STR3## wherein R.sub.1 is a member selected from the group consisting of hydrogen and alkyl having 1 to 3 carbon atoms and R.sub.2 is alkyl having 1 to 3 carbon atoms; as well as their water-soluble salts. The 1-hydroxy-3-amino-alkane-1,1-diphosphonic acids are excellent sequestering agents especially for alkaline earth metal ions. The compounds are useful in pharmaceutical preparations for treatment of disturbances of calcium or phosphate metabolism or cosmetic preparations such as toothpastes or mouthwashes for the prevention of tartar and plaque depositions.

REFERENCES:
patent: 3617343 (1971-11-01), Kandler et al.
patent: 3705191 (1972-12-01), Kerst

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