[1-Hydroximino-2,2-disubstituted-5-indanyloxy-(or thio)]alkanoic

Details [1-Hydroximino-2,2-disubstituted-5-indanyloxy-(or thio)]alkanoic [1-Hydroximino-2,2-disubstituted-5-indanyloxy-(or thio)]alkanoic

1974-05-22

1976-08-10

Raymond, Richard L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602471R, 2602475R, 26029362, 260308D, 260470, 260471R, 260473F, 2605011, 26050121, 260516, 260520C, 260546, 260558S, 260559A, 260590FA, 424269, 424309, 424315, 424319, C07C13100

Patent

active

039742121

ABSTRACT:
[1-Hydroximino-2,2-disubstituted-5-indanyloxy-(or thio)]alkanoic acids and their salt, ester, anhydride, amide and 5-tetrazolyl derivatives are disclosed. The products display a dual pharmaceutical utility in that they exhibit diuretic, saluretic and uricosuric activity. The acid products are prepared by treating a 1-oxo-2,2-disubstituted-5-indanyloxy(or thio)alkanoic acids or derivatives thereof with hydroxylamine in the presence of a base.

REFERENCES:
patent: 3704314 (1972-11-01), Cragoe et al.
Wagner et al., Synthetic Organic Chemistry, John Wiley & Sons, Inc., New York, (1953), pp. 739 and 740.

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