1-Hydrocarbyloxyphenyl-1,2-diphenylalkene derivatives

Details 1-Hydrocarbyloxyphenyl-1,2-diphenylalkene derivatives 1-Hydrocarbyloxyphenyl-1,2-diphenylalkene derivatives

1980-04-29

1981-12-22

Helfin, Bernard

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

26034863, 424340, 424341, 568585, 568586, 568640, 568641, 568 52, C07C 43215, A01N 3114

Patent

active

043071112

ABSTRACT:
Triphenylalkene derivatives of the formula: ##STR1## wherein R.sup.1 is alkenyl, cycloalkenyl, cycloalkenylalkyl, halogenoalkenyl, hydroxyalkyl, dihydroxyalkyl, hydroxycycloalkyl, dihydroxycycloalkyl, hydroxycycloalkylalkyl, epoxyalkyl, alkoxyalkyl or alkylthioalkyl each of up to 10 carbon atoms, wherein R.sup.2 is alkyl of up to 6 carbon atoms, halogen or nitro and wherein ring A may optionally bear a halogen substituent or an alkoxy substituent of up to 4 carbon atoms. These compounds possess antioestrogenic activity and are useful in the treatment of anovulatory infertility and of breast tumours. Representative of the compounds is 1-p-allyloxyphenyl-trans-1,2-diphenylbut-2-ene. There are also disclosed processes for the manufacture of the compounds and pharmaceutical compositions containing them.

REFERENCES:
patent: 2301260 (1942-11-01), Davies et al.
patent: 2346049 (1944-04-01), Rohrmann
patent: 3320271 (1967-05-01), Lednicer
patent: 3712929 (1973-01-01), Middleton
patent: 3875242 (1975-04-01), Lednicer
patent: 3947520 (1976-03-01), Lednicer
Palopoli et al., Jour. of Medicinal Chemistry (1974), 17, 1333-1335.
Richardson, Biochemical Society Transactions (1973), 528-535.

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