1-Hydrocarbyl-pyrrole-2-acetic acid derivatives and their produc

Details 1-Hydrocarbyl-pyrrole-2-acetic acid derivatives and their produc 1-Hydrocarbyl-pyrrole-2-acetic acid derivatives and their produc

1978-11-27

1980-12-09

Lee, Mary C.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26032647, 2603265R, 26032662, C07D20734

Patent

active

042383960

ABSTRACT:
5-Cyano-1-hydrocarbylpyrrole-2-acetic acid is converted to 5-acyl-1-hydrocarbylpyrrole-2-acetic acid by reaction with a Grignard reagent followed by hydrolysis. The cyano compound, novel per se, is produced by reacting 1-hydrocarbyl-2-(2',2',2'-trihalo-1'-hydroxyethyl)pyrrole with a cyanating reagent under basic conditions. The latter pyrrole is in turn formed by reacting 1-hydrocarbylpyrrole with trihaloacetaldehyde such as chloral, preferably in the presence of added organic acid catalyst.

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Kharasch et al., "Grignard Reactions of Nonmetallic Substances", pp. 767-845 (1954).
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Kharasch et al., "Grignard Reactions of Non-metallic Substances", pp. 948-960 (1954).

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