Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1978-02-06
1980-04-29
Coughlan, Jr., Paul M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
544364, 544368, 544370, 546193, 546194, 546198, 546199, 546216, A61K 31445, C07D40106
Patent
active
042006414
ABSTRACT:
Novel 1-[(heterocyclyl)alkyl]-4-diarylmethoxy piperidine derivatives are disclosed having the formula ##STR1## where n is 2-6, Ar.sup.1 and Ar.sup.2 are aryl and B is a substituted benzimidazolyl radical. These compounds are useful for their antianaphylactic and antihistaminic properties. Specific claimed compounds are 1-{3-[4-(diphenylmethoxy)-1-piperidinyl]-propyl}-1,3-dihydro-2H-benzimidaz ol-2-one, 1-{2-[4-(diphenylmethoxy)-1-piperidinyl]ethyl}1-, 3-dihydro-2H-benzimidazol-2-one, and 1-{4-[4-(diphenylmethoxy)-1-piperidinyl]butyl}-1,3-dihydro-2H-benzimidazol -2-one.
REFERENCES:
patent: 4021564 (1977-05-01), Hernestam et al.
patent: 4031226 (1977-06-01), Soudijn et al.
patent: 4035369 (1977-07-01), Vandenberk et al.
Kennis Ludo E. J.
Van der Aa Marcel J. M. C.
Van Heertum Albert H. M. Th.
Vandenberk Jan
Conte Salvatore R.
Coughlan, Jr. Paul M.
Janssen Pharmaceutica N.V.
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