Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1983-09-12
1985-06-18
Hollrah, Glennon H.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
544295, 544364, 544368, 544372, 548411, 548545, 549331, 549477, 260465D, 260465H, 562489, C07D40314, C07D 31495
Patent
active
045242062
ABSTRACT:
Disubstituted N,N'-piperazinyl derivatives are disclosed wherein one substituent is heteroaryl and the other is alkylene attached to the ring nitrogen of substituted 2,5-pyrrolidinedion-1-yl moieties. The substitution pattern of the pyrrolidinedione ring involves either geminal disubstitution, including spiro ring fusion, or 3,4-phenyl ring fusion to give phthalimide derivatives. Heteroaryl substitution on the other piperazine nitrogen comprises pyridine, pyrimidine, and benzisothiazole ring systems. Representative examples of these compounds demonstrate useful central nervous system effects.
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New James S.
Yevich Joseph P.
Hollrah Glennon H.
Mead Johnson & Company
Ryan Richard P.
Turnipseed James H.
Uloth Robert H.
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