1-glyoxylamide indolizines for treating cancer

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S313000, C514S314000, C546S112000, C546S159000, C546S162000

Reexamination Certificate

active

06861436

ABSTRACT:
Disclosed is a compound represented by Structural Formula (I):Ring A is substituted or unsubstituted and optionally fused to an aryl group.Z1and Z2are independently ═O, ═S, ═N—OR12or ═NR12R1and R2are independently —H, an aliphatic group, a substituted aliphatic group, an unsubstituted non-aromatic heterocylic group, a substituted non-aromatic heterocylic group, an aryl group or a substituted aryl group, provided that R1and R2are not both —H. Alternatively, —NR1R2, taken together, is a substituted or unsubstituted non-aromatic nitrogen-containing heterocyclic group or a substituted or unsubstituted nitrogen-containing heteroaryl group.R3is a substituted or unsubstituted aryl group or a substituted or unsubstituted aliphatic group.X is a covalent bond, —C(R4R5)—, —N(R4)—, —O—, —S—, —S(O)—, —S(O)2—, —C(═O)—, —C(═O)—N(R4)—, or —N(R4)—C(═O)—.R4and R5are independently —H or a substituted or unsubstituted aliphatic group.R12is —H or a substituted or unsubstituted alkyl group.

REFERENCES:
patent: 6214855 (2001-04-01), Gemba et al.
patent: 1085021 (2001-03-01), None
patent: 1157704 (2001-11-01), None
patent: 2287706 (1995-09-01), None
patent: WO9959999 (1999-11-01), None
patent: WO0021563 (2000-04-01), None

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