1-formyl-5,8,10-trideazafolates

Details 1-formyl-5,8,10-trideazafolates 1-formyl-5,8,10-trideazafolates

1991-11-27

1992-09-08

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514249, 514260, 514258, 544258, 544279, 544287, C07D40102, A61K 31505

Patent

active

051458543

ABSTRACT:
A 10-deaza-10-formyl folate analogue is a potent inhibitor of the enzyme glycinamide ribonucleotide formyltransferase and an antitumor agent. A typical embodiment is 10-formyl-5,8,10-trideazafolic acid (FTDF).

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patent: 4981856 (1991-01-01), Hughes et al.
patent: 4992550 (1991-02-01), Hughes
Nair, Nanavati et al. J. Med. Chem 29, 1754, 1986.
Nair et al. J. Med. Chem 30, 1256, 1987.

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