1-Ethanamine-triazolo-benzodiazepines as diuretics

Details 1-Ethanamine-triazolo-benzodiazepines as diuretics 1-Ethanamine-triazolo-benzodiazepines as diuretics

1983-03-17

1985-04-30

Rollins, Alton D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

2602393D, 2602444, 2602455, A61K 3155, C07D48704

Patent

active

045144079

ABSTRACT:
Triazolo-benzodiazepine-1-ethanamines of the formulas ##STR1## where R, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and Ring A are as defined in the specification, e.g., 8-chloro-N,N-dimethyl-.beta.,6-diphenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benz odiazepine-1-ethanamine, and pharmacologically acceptable salts thereof, have been found to have substantial diuretic, natriuretic, but little, if any, kaliuretic activity, which can be used alone, or concomittently with other diuretic drugs such as furosemide or hydrochlorothiazide and/or with antihypertensive agents such as propranolo, captopril, minoxidil, prazosin, guanadrel sulfate, whose actions are supplemented by the action of a diuretic drug.

REFERENCES:
patent: 3759943 (1973-09-01), Hester, Jr.
patent: 3767661 (1973-10-01), Hester, Jr.
patent: 3969504 (1976-07-01), Hester, Jr.
patent: 3987052 (1976-10-01), Hester, Jr.
patent: 3994940 (1976-11-01), Hester, Jr.
patent: 4012413 (1977-03-01), Hester, Jr.
patent: 4075221 (1978-02-01), Hester, Jr.
patent: 4375473 (1983-03-01), Rudzik
patent: 4455307 (1984-06-01), Hester, Jr.
Physicians' Desk Reference (PDR), 34th Edit. (1980), Publisher. Chas. E. Baker, Jr., pp. 216-217.
Roseberry et al, Biometrics, 20, (1964), pp. 73-84.

Affiliated with

Also associated with

Rating

1-Ethanamine-triazolo-benzodiazepines as diuretics does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 1-Ethanamine-triazolo-benzodiazepines as diuretics, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1-Ethanamine-triazolo-benzodiazepines as diuretics will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1967936