1-[(Dialkylamino)met hyl]-6-phenyl-4H-s-[4,3,-a][1,4]triazoloben

Details 1-[(Dialkylamino)met hyl]-6-phenyl-4H-s-[4,3,-a][1,4]triazoloben 1-[(Dialkylamino)met hyl]-6-phenyl-4H-s-[4,3,-a][1,4]triazoloben

1978-09-08

1980-10-07

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424269, A61K 3155

Patent

active

042267722

ABSTRACT:
The compound of the formula ##STR1## wherein R' and R" are alkyl of 1 to 3 carbon atoms, inclusive; wherein R.sub.1 is hydrogen, fluoro, chloro, bromo, nitro, trifluoromethyl or alkylthio in which the alkyl moiety is of 1 to 3 carbon atoms, inclusive; and wherein R.sub.2 is phenyl, o-chlorophenyl, o-fluorophenyl, or 2,6-difluorophenyl, is prepared by reacting a 1-halomethyl-6-phenyl-4H-s-triazo[4,3-a][1,4]-benzodiazepine with N,N-dimethylhydroxylamine and a strong base. The compound II and its pharmacologically acceptable acid addition salts have sedative and tranquilizing activity.

REFERENCES:
patent: 2500131 (1950-03-01), Linsker
patent: 2518130 (1950-08-01), Evans et al.
patent: 3681343 (1972-08-01), Hester
patent: 3842090 (1974-10-01), Gall et al.
Smith, Open-Chain Nitrogen Compounds, vol. 2, (W. A. Benjamin, Inc., New York, 1966), p. 28.
Merck Index, (9th Edition, Merck & Co., Inc., 1976), pp. 264, 394.

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