1-desamino-8-D-arginyl vasopressin analogs

Details 1-desamino-8-D-arginyl vasopressin analogs 1-desamino-8-D-arginyl vasopressin analogs

2007-09-04

2007-09-04

Russel, Jeffrey Edwin (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Oxytocin; vasopressin; related peptides

C514S011400, C514S016700

Reexamination Certificate

active

10540841

ABSTRACT:
Analogs of 1-desamino-8-D-arginyl vasopressin having the formula:wherein, X and Y are amino acids as defined herein, useful as an anti-diuretic or as an inhibitor of metastasis and cancer cell migration.

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Cort et al. Biological and Chiroptical Sequelae of Graded Alkyl Substitutions in the Vasopressin Ring. Molecular Pharmacology. 1976, vol. 12, pp. 313-321.
Hedenstrom et al. Conformations and Receptor Activity of Desmopressin Analogues . . . Journal of Medicinal Chemistry. May 4, 2002, vol. 45, No. 12, pp. 2501-2511.
Vilhardt et al. Antidiuretic activity and release of Factor VIII by vasopressin analogues. European Journal of Pharmacology. 1993, vol. 232, pp.223-226.
Manning et al. Design of vasopressin agonists . . . Peptides 2002, Proceedings of the 27th European Peptide Symposium. 2002, pp. 554-555.

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