Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-07-23
1989-08-08
Sutto, Anton H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546156, 544363, 544389, 544395, 548557, 548567, 548568, 558 54, 558388, 558418, 558425, 560 53, 560 51, 560103, 562493, 562494, 564215, 564440, 564441, 564442, 260544R, 568812, 568938, 568709, 570182, A61K 3147, C07D40104
Patent
active
048552925
ABSTRACT:
Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.2 is 1-pyrrolidinyl which may have 1 to 2 substituents selected from the group consisting of (i) C.sub.1 -C.sub.6 alkyl, (ii) amino-(C.sub.1 -C.sub.6)alkyl, said amino being optionally substituted by 1 or 2 substituents selected from C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkanoyl, and C.sub.1 -C.sub.6 alkoxycarbonyl, (iii) amino which may be substituted by 1 or 2 substituents selected from C.sub.1 -C.sub.6 alkyl, phenyl(C.sub.1 -C.sub.6)alkyl, C.sub.1 -C.sub.6 alkoxycarbonyl, and C.sub.1 -C.sub.6 alkanoyl, and (iv) 2-oxo-1,3-dioxolenemethylamino which is substituted by C.sub.1 -C.sub.6 alkyl; or 1-piperidinyl which may have 1 to 3 substituents selected from oxo, hydroxy, halogen and C.sub.1 -C.sub.6 alkyl, and R.sup.3 is C.sub.1 -C.sub.6 alkyl, or a pharmaceutically acceptable salt thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition containing said compound as an active ingredient.
REFERENCES:
patent: 4544747 (1985-10-01), Ishikawa et al.
patent: 4556658 (1985-12-01), Grohe et al.
patent: 4563459 (1986-01-01), Grohe et al.
patent: 4578473 (1986-03-01), Domagala et al.
patent: 4705788 (1987-11-01), Schriewer et al.
patent: 4753953 (1988-06-01), Masuzawa et al.
Masuzawa et al., Chemical Abstracts, vol. 108, No. 75 234m (1988).
Research Disclosure 269024 "Use of Gyrase Inhibitors in Aerosol Form for Treating Respiratory Infections", (Sep. 1986).
Research Disclosure 269008 "Use of Gyrase Inhibitors for Treating Infections by Rectal or Vaginal Administration", (Sep. 1986).
Derwent Abstract No. 86-309519/47 for Japan Patent 229877 (10/14/86).
Derwent Abstract No. 86-193394/30 for Japan Patent 1126-082 (6/13/86).
Derwent Abstract No. 85-305531/49 for Japan Patent 166681 (8/29/85).
Aki Shinji
Miyamoto Hisashi
Otsuka Tatsuya
Ueda Hiraki
Bernhardt E.
Otsuka Pharmaceutical Company Limited
Sutto Anton H.
LandOfFree
1-cyclopropyl-6-fluoro-8-alkyl-1,4-dihydro-4-oxo-quinoline-3-car does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 1-cyclopropyl-6-fluoro-8-alkyl-1,4-dihydro-4-oxo-quinoline-3-car, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1-cyclopropyl-6-fluoro-8-alkyl-1,4-dihydro-4-oxo-quinoline-3-car will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-905733