1-(Cyclohexyl)-4-aryl-4-piperidinecarboxylic acid derivatives

Details 1-(Cyclohexyl)-4-aryl-4-piperidinecarboxylic acid derivatives 1-(Cyclohexyl)-4-aryl-4-piperidinecarboxylic acid derivatives

1980-09-29

1983-01-18

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

546187, 546189, 546194, 546208, 546213, 546225, 546228, 544124, 544130, 42424855, A61K 31445, A61K 31535, C07D21164, C07D26530

Patent

active

043691846

ABSTRACT:
Novel 1-(cyclohexyl)-4-aryl-4-piperidinecarboxylic acid derivatives, bearing in the 4-position of the cyclohexyl ring a cyano group and an aryl moiety, said compounds displaying useful antihistaminic properties.

REFERENCES:
M. M. Abdel-Monem, et al., Correlation of Analgesic Potencies of N-Substituted Normeperidines and in Vitro N-Dealkylation, (1971), J. Pharm. Pharmac., vol. 23, pp. 875-876.
Larson, et al., Relationship Between Analgetic ED.sub.50 Dose and Time-Course Brain Levels of N-Alkylnormeperidine Homologues (1976), J. of Medicinal Chem., vol. 19, No. 1, pp. 16-19.
Pert, et al., Correlation of Opiate Receptor Affinity with Analgetic Effects of Meperidine Homologues, (1976), J. of Medicinal Chem., vol. 19, No. 10, pp. 1248-1250.

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