Organic compounds -- part of the class 532-570 series – Organic compounds – Phosphorus containing
Patent
1982-03-29
1983-08-02
Sneed, Helen M. S.
Organic compounds -- part of the class 532-570 series
Organic compounds
Phosphorus containing
568 11, C07F 954, C07F 950
Patent
active
043967779
ABSTRACT:
1-Cycloalkyl phosphonium salts represented by the formula ##STR1## wherein: R is selected from the group consisting of lower alkyl, hydroxy lower alkyl, halo lower alkyl, amino lower alkyl, cyano lower alkyl, lower alkenyl with the limitation that the double bond is not on the carbon atom attached to the oxygen atom, benzyl, substituted benzyl and ##STR2## wherein q is O or 1 and R.sub.4 is selected from the group consisting of hydroxy, loweralkoxy, phenyl, substituted phenyl, and ##STR3## wherein R.sub.5 and R.sub.6 are the same or different members of the group consisting of hydrogen and loweralkyl or taken together form a 5 or 6 membered ring; m is 1, 2 or 3; n is 0 or 1; o is 0 or 1; p is 0 or 1; R.sub.1, R.sub.2 and R.sub.3 are the same or different members of the group consisting of hydrogen, lower alkyl, lower alkoxy and halo; and X is a pharmaceutically acceptable anion. The compounds are useful as analgesic agents.
REFERENCES:
patent: 3294820 (1966-12-01), Hudson et al.
patent: 3424799 (1969-01-01), Chopard et al.
patent: 3449438 (1969-06-01), Freyschlag et al.
patent: 3634518 (1972-01-01), Buddrus
patent: 3654372 (1972-04-01), Birum et al.
patent: 4075407 (1978-02-01), Mueller
patent: 4297487 (1981-10-01), Mueller
G. D. Searle & Co.
Passe James G.
Sneed Helen M. S.
Tockman Albert
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