1-(carbamyl, thiocarbamyl, and iminocarbamyl)-indoline derivativ

Details 1-(carbamyl, thiocarbamyl, and iminocarbamyl)-indoline derivativ 1-(carbamyl, thiocarbamyl, and iminocarbamyl)-indoline derivativ

1985-09-05

1987-05-12

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548491, 548492, 548430, A61K 31405, C07D20926

Patent

active

046650873

ABSTRACT:
1-(Carbamyl, thiocarbamyl, and iminocarbamyl)-indoline derivatives of the formula ##STR1## where each R.sub.1 is independently alkyl, alkoxy, acyloxy, hydroxy, halo or trifluoromethyl, n is 0, 1, 2 or 3, R.sub.2 and R.sub.3 are independently hydroxy, alkoxy, amino or substituted amino, R.sub.4 and R.sub.5 are independently hydrogen, alkyl or substituted alkyl, R.sub.6 is hydrogen, alkyl or substituted alkyl, and Y is O, S or N--R.sub.7 where R.sub.7 is hydrogen, alkyl, cyano or substituted alkyl, and salts thereof, which are useful as antihypertensive and cardioactive agents, methods of preparing the same, and pharmaceutical compositions thereof, are provided.

REFERENCES:
patent: 3780062 (1973-12-01), Kaiser et al.
patent: 3796723 (1974-03-01), Kaiser et al.
patent: 4179434 (1979-12-01), Ondetti et al.
patent: 4256751 (1981-03-01), Hayashi et al.
patent: 4294832 (1981-10-01), Yoneda et al.
patent: 4303583 (1981-12-01), Kim et al.
patent: 4344949 (1982-08-01), Hoefle et al.
patent: 4350704 (1982-09-01), Hoefle et al.
patent: 4374829 (1983-02-01), Harris et al.
patent: 4374847 (1983-02-01), Gruenfeld
patent: 4390700 (1983-06-01), Stanton et al.
patent: 4402969 (1983-09-01), Greenlee et al.
patent: 4404206 (1983-09-01), Vincent et al.
patent: 4515803 (1985-05-01), Henning et al.
Derwent Abstract 836003 of Japan 5-8185-565, published Oct. 29, 1983.

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