1-Carbamoyl-5-fluorouracil derivatives

Details 1-Carbamoyl-5-fluorouracil derivatives 1-Carbamoyl-5-fluorouracil derivatives

1975-11-05

1978-01-31

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424251, C07D23910, A61K 31505

Patent

active

040715191

ABSTRACT:
1-Carbamoyl-5-fluorouracil derivatives represented by the formula ##STR1## wherein R represents alkyl containing 3-8 carbon atoms are effective oral anti-tumor agents with low toxicity.

REFERENCES:
hoshi, et al., "Pharmacometrics", vol. 3(1), 1969, pp. 57-60.
Hoshi, et al., "Gann", vol. 60, 1969, pp. 115-117.
Owens, "J. Chron. Dis.", vol. 15, 1962, pp. 223-228.
Freireich, et al., "Cancer Chemotherapy Report", vol. 50 (4), 1956, pp. 219-244.
Heidelberger, et al., "Proc. Soc. Exptl. Biol. Med.", vol. 97, 1958, pp. 470-475.

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