Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1987-06-26
1988-12-13
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540205, A61K 31435, C07D47104
Patent
active
047911069
ABSTRACT:
7.beta.-Acylamino-3-alkoxycarbonyl-(and 3-keto)-1-carba(1-dethia)-3-cephem-4-carboxylic acids and derivatives and related 3-substituted compounds are provided as antibiotics useful for treating infections in man and animals. Pharmaceutical formulations comprising the antibiotics and intermediates a process for their preparation are provided. Exemplary compounds provided are 7.beta.-[D-(2-phenyl-2-aminoacetyl)amino]-3-methoxycarbonyl-1-carba(1-deth ia)-3-cephem-4-carboxylic acid and 7.beta.-[2-(2-aminothiazol-4-yl)-2-methoxyimino-acetamido]-3-acetyl-1-carb a(1-dethia)-3-cephem-4-carboxylic acid.
REFERENCES:
patent: 4174136 (1979-11-01), Christensen et al.
patent: 4226866 (1980-10-01), Christensen et al.
Uyeo, S., et al., "Synthesis of 1-Carbacephem Derivatives", Chem. Pharm. Bull., 28, 1563-1577 (1980).
Hatanaka, M., et al., Tetrahedron Letters, vol. 24, No. 44, pp. 4837-4838 (1983).
Hirata, T., et al., Chem. Abst., 93:239247t.
EPO Search Report in applicant's EPO application corresponding to applicant's parent application Ser. No. 814,943, filed Dec. 30, 1985.
Daus Donald G.
Eli Lilly and Company
Scanlon William B.
Shen Cecilia
Whitaker Leroy
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