1-carbacephalosporin antibiotics

Details 1-carbacephalosporin antibiotics 1-carbacephalosporin antibiotics

1988-08-24

1990-01-09

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20508

Patent

active

048929425

ABSTRACT:
7.beta.-Acylamino-3-alkoxycarbonyl-(and 3-keto)-1-carba(1-dethia)-3-cephem-4-carboxylic acids and derivatives and related 3-substituted compounds are provided as antibiotics useful for treating infections in man and animals. Pharmaceutical formulations comprising the antibiotics and intermediates a process for their preparation are provided. Exemplary compounds provided are 7.beta.-[D-(2-phenyl-2-aminoacetyl)amino]-3-methoxycarbonyl-1-carba(1-deth ia)-3-cephem-carba(1-dethia)-3-cephem-4-carb oxylic acid and 7.beta.-[2-(2-aminothiazol-4-yl)-2-methoxyimino-acetamido]-3-acetyl-1-carb a(1-dethia)-3-cephem-4-carboxylic acid.

REFERENCES:
patent: 4174136 (1979-11-01), Christensen et al.
Uyeo, S. et el., "Synthesis of 1-Carbacephem Derivatives", Chem. Pharm. Bull., 28, 1563-1577 (1980).
Hatanaka, M. et al., Tetrahedron Letters, vol. 24, no. 44, pp. 4837-4838 (1983).
Hirata, T. et al., Chem. Abst., 93:239247t.

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