1-carbacephalosporin antibiotics

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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Details

540205, C07D47104, C07D47300, A61K 31435, A61K 3147

Patent

active

050195719

ABSTRACT:
This invention relates to antibacterial compounds of the formula ##STR1## wherein A is hydrogen or an acyl group ##STR2## R.sub.a is a negative charge; R.sub.z is hydrogen, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, or a formamido group, --NHCHO; and --N.sup..sym. .tbd.Y is a quarternary ammonium group that may be acyclic, cyclic, or a combination of the two, and may contain on or more additional hetero atoms selected from nitrogen, sulfur and oxygen; and pharmaceutically acceptable non-toxic salts thereof.

REFERENCES:
patent: 4013651 (1977-03-01), Spitzer
patent: 4396619 (1983-08-01), Lunn et al.
patent: 4396620 (1983-08-01), Lunn
patent: 4486586 (1094-12-01), Narita et al.
patent: 4558124 (1985-12-01), Corfield et al.
patent: 4665065 (1987-05-01), Miyake et al.
patent: 4665171 (1987-05-01), Evans et al.
patent: 4673737 (1987-06-01), Evans et al.
Merck Index, 1989, (11th Edition) p. 304.
Chemical Abstracts 106, 32696e (1986).

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