1-carba(dethia)-3-hydroxy-3-cephem ester crystalline and crystal

Details 1-carba(dethia)-3-hydroxy-3-cephem ester crystalline and crystal 1-carba(dethia)-3-hydroxy-3-cephem ester crystalline and crystal

1987-09-14

1988-11-01

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D47104

Patent

active

047821442

ABSTRACT:
Crystalline p-nitrobenzyl 7.beta.-phenoxyacetylamino-3-hydroxy-1-carba(dethia)-3-cephem-4-carboxylat e and the crystalline mono-acetic acid solvate thereof are provided by mixing a carboxylic acid or a sulfonic acid with a solution of the 3-hydroxy ester in DMF or DMAC. Acetic acid provides the crystalline acetic acid solvate while other acids provide crystalline non-solvated 3-hydroxy ester. The crystalline forms are useful purified intermediates to antibiotics.

REFERENCES:
patent: 4237279 (1980-12-01), Fisher
patent: 4665171 (1987-05-01), Evans et al.
Hatanaka, M., et al., Tetrahedron Letters, vol. 24, No. 44, pp. 4837-4838, 1983.
Evans, D. A. et al., Tetrahedron Letters, vol. 26, No. 32, pp. 3783-3786, 1985.
Evans, D. A. et al., Tetrahedron Letters, vol. 26, No. 32, pp. 3787-3790, 1985.

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