1-(biphenyl-4-ylmethyl)imidazolidine-2,4-dione

Details 1-(biphenyl-4-ylmethyl)imidazolidine-2,4-dione 1-(biphenyl-4-ylmethyl)imidazolidine-2,4-dione

2011-06-14

2011-06-14

Saeed, Kamal A (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S318500, C548S319500, C548S320500, C546S210000, C544S060000, C544S139000, C514S277000, C514S235800, C514S326000, C514S389000

Reexamination Certificate

active

07960560

ABSTRACT:
The invention relates to A 1-(biphenyl-4-ylmethyl)imidazolidine-2,4-dione derivative having the general Formula Iwherein R1is H, (C1-6)alkyl (optionally substituted with oxo, OR4, COOR5, halogen or CN), (C2-6)alkenyl, (C2-6)alkynyl, (C3-6)cycloalkyl or (C3-6)cycloalkyl(C1-3)alkyl; R2and R2′ are independently H or (C1-3)alkyl; or R2and R2′ form together with the carbon atom to which they are bound a (C3-5)cycloalkyl group; R3represents H or 1 to 4 F substituents; Y representsor NR8R9; X represents CHR6, CF2, O, S, SO or SO2; R4and R5are (C1-6)alkyl; R6is H, OR7or CN; R7is (C1-3)alkyl; R8is (C5-7)cycloalkyl comprising a heteroatom selected from O, S, SO and SO2; R9is H or (C1-4)alkyl; o and m represent the ortho or meta position of the substituent Y—CH2; or a pharmaceutically acceptable salt thereof; as well as to the use of said 1-(biphenyl-4-ylmethyl)imidazolidine-2,4-dione derivatives in the treatment of pain such as for example peri-operative pain, chronic pain, neuropathic pain, cancer pain and pain and spasticity associated with multiple sclerosis.

REFERENCES:
patent: WO 01/56996 (2001-08-01), None
patent: WO 2004/018433 (2004-03-01), None
patent: WO 2007/070760 (2007-06-01), None
International Search Report for PCT/EP2009/066156 filed Jan. 12, 2009 mailed on Jan. 19, 2010; 4 pages.
Written Opinion for PCT/EP2009/066156 filed Jan. 12, 2009 mailed on Jan. 19, 2010; 5 pages.
Govaerts Sophie, J. et. al.; “Characterization of the pharmacology of imidazolidinedione derivatives at cannabinoid CB1 and CB2 receptors”, European Journal of Pharmacology; vol. 495, No. 1; Jul. 8, 2004; pp. 43-53.
International Search Report for PCT/EP2009/066030 filed Nov. 30, 2009 mailed on May 2, 2010; 4 pages.

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