1-.beta.-methyl-2-thiolic carbapenem derivatives

Details 1-.beta.-methyl-2-thiolic carbapenem derivatives 1-.beta.-methyl-2-thiolic carbapenem derivatives

1993-11-19

1995-10-31

Rizzo, Nicholas

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D48704, A61K 3140

Patent

active

054630460

ABSTRACT:
The present invention relates to new 1-.beta.-methyl-2-thiolic carbapenem derivatives represented by the following general formula (I) and producing method thereof. ##STR1## The above-mentioned compound is very stable against DHP-1 enzyme due to effective shielding of carbapenem ring structually and is highly effective in both gram-positive and gram-negative microorganism, especially has a remarkable effect on the Pseudomonas aeruginosa known as a disease germ having strong resistance.

REFERENCES:
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patent: 5310735 (1994-05-01), Kawamoto et al.
Chemical abstracts vol. 122: 160367 (1995).
Chemical abstracts vol. 120: 322991(1994).
Chemical abstracts vol. 108: 150152 (1988).
Recent Advances in The Chemistry Of .beta.-Lactam Antibiotics, Fourth International Symposium, P. H. Bentley and R. Southgate, eds., "Novel Carbapenems," T. N. Salzmann, et al., pp. 171 to 173. (Apr. 30, 1989).

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