Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-04-14
1989-02-21
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 70, C07D45500
Patent
active
048065455
ABSTRACT:
The invention relates to the new (-)-1.beta.-ethyl-1.alpha.-hydroxymethyl-1,2, 3,4,6,7,12,12b.alpha.-octa-hydroindolo[2,3-a] quinolizine of the formula (I) ##STR1## and acid addition salts thereof. According to another aspect of the invention there is provided a process for the preparation of the compound of formula (I) and acid addition salts thereof by resolution of the corresponding racemic compound and optionally by subsequent hydrolysis and/or salt formation.
The compound of formula (I) shows a remarkable peripheral vasodilating and antihypoxial activity. Pharmaceutical compositions comprising it as active ingredient are also within the scope of the invention.
REFERENCES:
patent: 4036841 (1977-07-01), Szantay et al.
Helv. Chem. Acta., 60, 1801-1810 (1977).
Gaz. Chem. Italiana, 111, 257-267 (1981).
Csomor Katalin
Forgacs Lilla
Gere Aniko
Kalaus Gyorgy
Karpati Egon
Cseh C. L.
Daus Donald G.
Dubno Herbert
Myers Jonathan
Richter Gedeon Vegyeszeti Gyar Rt.
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