1-(.beta.-D-xylofuranosyl)thymine derivatives

Details 1-(.beta.-D-xylofuranosyl)thymine derivatives 1-(.beta.-D-xylofuranosyl)thymine derivatives

1988-06-09

1990-04-10

Shen, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 23, 536122, C07H 1500, C07H 1700

Patent

active

049162187

ABSTRACT:
This invention relates to a new synthetic process for the manufacture of zidovudine from the starting material D-xylose involving:

REFERENCES:
Wilson et al., Chem. Abst. 111-23914a.
Watanabe et al., J. Med. Chem., 1980, 23, pp. 1088-1094.
Guiller, A. et al., J. Carbohydrate Chemistry 5(2), 153-160 (1986).
Guiller, A. et al., J. Carbohydrate Chemistry 5(2), 161-168 (1986).
Guiller, A. et al., Carbohydrate Research, vol. 180, No. 2, Sep. 15, 1988, 233-242.
Baraldi et al., J. Med. Chem., 1984, 27, 986-990, Pyrazolo[4.3-d] Pyrimidine Nucleosides . . .
Watanabe et al., J. Med. Chem., 1980, 23, 1088-1094, Nucleosides, 116 . . .
Russell et al., Biochemistry, Dec. 1969, 8(12), vol. 8, No. 12, Synthesis of Some Nucleotides Derived from 3'-Deoxythymidine.
Montgomery et al., J. Carbohydrates-Nucleosides-Nucleotides, 2(2), 147-151 (1975), A Convenient Method for the Preparation of Methyl 2,3-Anhydro-.beta.-D-Ribofuranoside.

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