1.beta.,7,8-trihydroxy vitamin D.sub.2, 1.smallcircle.,7,8-trihy

Details 1.beta.,7,8-trihydroxy vitamin D.sub.2, 1.smallcircle.,7,8-trihy 1.beta.,7,8-trihydroxy vitamin D.sub.2, 1.smallcircle.,7,8-trihy

1992-05-06

1994-02-01

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549336, 556445, 556446, 556449, 560256, 568819, C07D31720, C07C 3521

Patent

active

052833453

ABSTRACT:
There are disclosed novel compounds that can be used to derive therefrom a fragment that corresponds to an A-ring which is to be comined with fragments which respectively correspond to C- and D-rings in synthetic formation of vitamin D.sub.3 derivatives by cleaving the 7,8-bondings by means of oxidizing agents following any known process. According to the invention, there is provided an industrially efficient and effective method of manufacturing above compounds that utilizes chemical reaction of allylic acid to add an oxygen function group to position C(1), a method which is completely different from any existing synthetic methods.

REFERENCES:
patent: 4755329 (1988-07-01), DeLuca et al.
Desmaele et al., "Synthesis of A-ring of 1S-hydroxykohlcalciferol", Tetrahydron Letters, 26:4941 (1985).
Okamura et al., "A Short, Enantiospecific Synthesis of the 1.alpha.-Hydroxyvitamin D Enyne A-Ring Synthon", Tetrahydron Letters, 28(42):4947-4950 (1987).
DeLuca et al., "Vitamin D: Recent Advances", Ann. Rev. Biochem., 52:411-419 (1983).
Ikegawa et al., "Synthesis of Active Forms of Vitamin D(I)--Recent Advances", Organic Synthetic Chem., 37:755 (1979).
Calverley, "Synthesis of MC 903, A Biologically Active Vitamin D Metabolite Analogue", Tetrahydron, 43(20):4609-4619 (1987).
Lythgoe "Synthetic Approaches to Vitamin D and its Relatives", Chem. Soc. Rev., 9:449 (1980).

Affiliated with

Also associated with

Rating

1.beta.,7,8-trihydroxy vitamin D.sub.2, 1.smallcircle.,7,8-trihy does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 1.beta.,7,8-trihydroxy vitamin D.sub.2, 1.smallcircle.,7,8-trihy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1.beta.,7,8-trihydroxy vitamin D.sub.2, 1.smallcircle.,7,8-trihy will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-580785