1-Azoniabicyclo[3.1.0]hexanes

Details 1-Azoniabicyclo[3.1.0]hexanes 1-Azoniabicyclo[3.1.0]hexanes

1977-11-17

1978-09-19

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26029354, 2603265M, 2603268, 26032687, C07D20952

Patent

active

041154002

ABSTRACT:
Novel 1,3,4-trisubstituted-4-arylpiperidines are prepared by alkylating a 2,3-disubstituted-3-arylpyrroline to afford a 1,2,3-trisubstituted-3-aryl-1-pyrrolinium salt, reacting the salt with diazomethane to provide a 1,2,3-trisubstituted-3-aryl-1,2-methylene-pyrrolidinium salt, heating the pyrrolidinium salt to effect a ring expansion to the corresponding 1,3,4-trisubstituted-4-aryl-1,4,5,6-tetrahydropyridinium salt, neutralizing the salt and reducing the tetrahydropyridine to provide a 1,3,4-trisubstituted-4-arylpiperidine. The piperidines so formed are useful as pharmacological agents and as intermediates in the preparation of other piperidines of the invention. The compounds provided herein are especially useful as narcotic agonists analgesics and as narcotic antagonists.

REFERENCES:
Chemical Abstracts, 76:71797v, (1972), [Hammer, C. et al., Tetrahedron 1972, 28(2), 239-253].

Affiliated with

Also associated with

Rating

1-Azoniabicyclo[3.1.0]hexanes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 1-Azoniabicyclo[3.1.0]hexanes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1-Azoniabicyclo[3.1.0]hexanes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2118942