1-aziridino-1-hydroxyiminomethyl-derivates, method for the...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S183000, C514S340000, C514S362000, C546S268100, C548S134000, C548S962000, C548S963000

Reexamination Certificate

active

07078418

ABSTRACT:
Described are new 1-aziridino-1-hydroxyiminomethyl derivatives with the general formula (I), wherein R is able to is a single bond or a linker moiety capable of covalently bonding two aziridine oxime groups, R1and R2independently of one another are selected from the group consisting of —H, —CH3, —C2H5, —CN, —COOH, —COOCH3, —COOC2H5, —CONH2, or —C6H5group, and n is the whole number 2, provided that R1and R2are not both —H and provided that R1is not —H if R2is —CH3and R1is not —CH3if R2is —H The compounds of general formula (I) show antitumor activity.

REFERENCES:
Eremeev, et al, 1982, Synthesis and Investingation of Aziridino Dioximes, 6, 369-374.
Tsou et al., Synthesis of Possible Cancer Chemotherapeutic Compounds Based on Enzyme Approach. IV. Aziridine Derivatives, Jul., 1963, pp. 435-439.
Musluo{hacek over (g)}lu et al. ‘Synthesis and Characterization of 1,2-Bis(aziridin-N-yl)glyoxime and its Nickel (II), Palladium (II) and Cobalt (II) Complexes,’ J. Chem. Research (S), p. 142-3 (1999) Chem. Abs.:115:48589u (1991).

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