Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-07-18
2006-07-18
Richter, Johann (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S183000, C514S340000, C514S362000, C546S268100, C548S134000, C548S962000, C548S963000
Reexamination Certificate
active
07078418
ABSTRACT:
Described are new 1-aziridino-1-hydroxyiminomethyl derivatives with the general formula (I), wherein R is able to is a single bond or a linker moiety capable of covalently bonding two aziridine oxime groups, R1and R2independently of one another are selected from the group consisting of —H, —CH3, —C2H5, —CN, —COOH, —COOCH3, —COOC2H5, —CONH2, or —C6H5group, and n is the whole number 2, provided that R1and R2are not both —H and provided that R1is not —H if R2is —CH3and R1is not —CH3if R2is —H The compounds of general formula (I) show antitumor activity.
REFERENCES:
Eremeev, et al, 1982, Synthesis and Investingation of Aziridino Dioximes, 6, 369-374.
Tsou et al., Synthesis of Possible Cancer Chemotherapeutic Compounds Based on Enzyme Approach. IV. Aziridine Derivatives, Jul., 1963, pp. 435-439.
Musluo{hacek over (g)}lu et al. ‘Synthesis and Characterization of 1,2-Bis(aziridin-N-yl)glyoxime and its Nickel (II), Palladium (II) and Cobalt (II) Complexes,’ J. Chem. Research (S), p. 142-3 (1999) Chem. Abs.:115:48589u (1991).
Adrianov Viktor
Domracheva Ilona
Kalvins Ivars
Kanepe Iveta
Shestakova Irina
Kalvins Ivars
Kriegsman & Kriegsman
Sackey Ebenezer
LandOfFree
1-aziridino-1-hydroxyiminomethyl-derivates, method for the... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 1-aziridino-1-hydroxyiminomethyl-derivates, method for the..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1-aziridino-1-hydroxyiminomethyl-derivates, method for the... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3581819