Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-06-13
1996-07-23
Springer, David B.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
548454, 548455, C07D40312, C07D40512, C07D48704, A61K 3140
Patent
active
055391257
ABSTRACT:
There are disclosed a 1-azabicyclo[3.3.0]octan derivative of the formula ##STR1## wherein n is an integer of 1-5; and Ar is an aromatic residue. a pharmacologically acceptable salt of the compound, a process for the preparation of the compound and salt as well as use thereof as hypermotility agents.
REFERENCES:
The Merck Index, 10th Ed. (1984) Entry No. 6063 p. 965.
"Novel Benzamides as Selective and Potent Gastrokinetic Agents. 2..sup.1 Synthesis and Structure-Activity Relationships of 4-Amino-5-chloro-2-ethoxy-N-[[4-(4-flurobenzyl)-2-morpholinyl]methyl]benza mide Citrate As-4370) and Related Compounds," Kato et al., J. Med. Chem., 1991, 34, pp. 616-624.
"5-Hydroxytryptamine.sub.4 receptors mediate relaxation of the rat oesophageal tunica muscularis mucosae," G. S. Baxter et al., Naunyn-Schmiedeberg's Archives of Pharmacology, 1991, vol. 343 pp. 439-446.
Abstract of the 98th Annual Lecture Meeting in the Pharmacological, Society of Japan, p. 223, Apr. 3-5, 1978 (Engl. Trans 1.).
Baba Yutaka
Itoh Nobuyuki
Kakigami Takuji
Ozeki Yoshiro
Tsukamoto Katsura
Sanwa Kagaku Kenkyusho Co. Ltd.
Springer David B.
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