[(1-arylpyrrolidin-2-yl)methyl]piperazine derivatives, their pre

Details [(1-arylpyrrolidin-2-yl)methyl]piperazine derivatives, their pre [(1-arylpyrrolidin-2-yl)methyl]piperazine derivatives, their pre

1991-06-06

1993-03-09

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544225, 544372, 548572, H61K 31495, C07D40306

Patent

active

051927632

ABSTRACT:
[(1-Arylpyrrolidin-2-yl)methyl]piperazine compounds corresponding to the formula ##STR1## in which Z denotes a group of formula N-R.sub.1 in which R.sub.1 is either a hydrogen atom or a C.sub.1-3 alkyl group or a group of formula Ar--C.sub.n H.sub.2n in which n denotes 0, 1 or 2 and Ar denotes a phenyl group optionally substituted by one or more halogen atoms and/or C.sub.1-3 alkyl or C.sub.1-3 alkoxy radicals, or a group of formula COR.sub.2 in which R.sub.2 denotes the CH.sub.3, C.sub.6 H.sub.5, CH.sub.2 C.sub.6 H.sub.5 or OC.sub.2 H.sub.5 group and their salts of addition to pharmaceutically acceptable acids. The compounds are useful for the treatment of neurological disorders.

REFERENCES:
patent: 3250771 (1966-05-01), Leonard et al.
patent: 5063242 (1991-11-01), Horwell et al.
Monnet et al, J. Pharm. Exp. Ther. 261, p. 123 (1992).
Greenamyre, Arch. Neurol. 43, p. 1058 (1986).
Olney, Biol. Psychiatry 26, p. 505 (1989).

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