1-aryloxy-3-alkylamino-2-propanol nitrate esters, the use thereo

Details 1-aryloxy-3-alkylamino-2-propanol nitrate esters, the use thereo 1-aryloxy-3-alkylamino-2-propanol nitrate esters, the use thereo

1995-08-11

1997-06-17

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 23, 560156, 564165, 568583, 568587, C07C20501

Patent

active

056399049

ABSTRACT:
The 1-aryloxy-3-alkylamino-2-propanol nitrate esters, having formula I: ##STR1## the enantiomers and diastereoisomers and the therapeutically acceptable salts thereof, wherein R.sub.1 is a chain of general formula II --(CH.sub.2).sub.m --Z--R.sub.2, where: m is 1 or 2; Z is an --O-- ether, --CONH amide or --COO-- ester function; and R.sub.2 is a C.sub.2-3 straight or branched chain alkyl having at least one nitroxy group as substituent; and Ar is a benzene ring when Z is the ether or ester function, and a naphthalene ring when Z is the amide function, are of use for the treatment of cardiovascular affections.

REFERENCES:
patent: 3873600 (1975-03-01), Brandstrom et al.
patent: 4374840 (1983-02-01), Shiratsuchi et al.
patent: 4448989 (1984-05-01), Shiratsuchi et al.

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