1-Aryloxy-2-hydroxy-3-aminopropanes

Details 1-Aryloxy-2-hydroxy-3-aminopropanes 1-Aryloxy-2-hydroxy-3-aminopropanes

1978-08-10

1980-03-04

Torrence, Dolph H.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

26032647, 2603265M, 2603405R, 260465E, 26050117, 544163, 544171, 544230, 544238, 544360, 544383, 544394, 544399, 544401, 546194, 546230, 546238, 560 21, 560 42, 562435, 562451, 42424855, 42424858, 424250, 424267, 424274, 424282, 424304, 424309, 424316, 424317, A61K 31215, A61K 31275, C07C 6976, C07C12180

Patent

active

041917650

ABSTRACT:
Compounds of formula I ##STR1## wherein R.sup.1 and R.sup.1' are identical or different and represent hydrogen, an alkyl radical or alkoxy radical having 1-4 carbon atoms, the allyl group, a halogen atom or the nitro group, R.sup.2 represents an acrylic acid radical or an acrylic acid nitrile radical of the formulae ##STR2## wherein R.sup.5 represents hydrogen, an alkyl radical having 1-5 carbon atoms, an aryl radical or aryl-lower alkyl radical either unsubstituted or substituted by lower alkyl or alkoxy, R.sup.6 represents hydrogen or an alkyl radical having 1-8 carbon atoms, R.sup.7 represents hydrogen, a lower alkyl radical or an aryl-lower alkyl radical, R.sup.3 and R.sup.4 represent together with the nitrogen atom a heterocyclic ring with 5-7 members being optionally substituted by C.sub.1 -C.sub.4 alkyl, in which ring one carbon atom may be replaced by one oxygen atom, sulfur atom or one further nitrogen atom, the latter may be substituted, or wherein R.sup.3 represents hydrogen and R.sup.4 represents a phenyl-alkylene or phenyl-alkylidene radical of the formula ##STR3## in which Alk is alkyl having 1 to 3 carbon atoms, and n is a figure from 1-3, and R.sup.8 and R.sup.9 are identical or different and represent hydrogen, an alkoxy radical having 1-3 carbon atoms or the benzoyl radical or R.sup.8 and R.sup.9 represent together the bismethylene dioxy radical, as well as the physiologically compatible acid addition salts and a process for preparing these compounds.

REFERENCES:
patent: 3644469 (1972-02-01), Koppe et al.
patent: 3663607 (1972-05-01), Barrett et al.
patent: 3857873 (1974-12-01), Schwender et al.
patent: 4014920 (1977-03-01), Jaeggi et al.

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