Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-02-05
1993-07-27
Higel, Floyd D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514319, 514324, 514321, 514325, 546193, 546196, 546203, 546212, 546213, 546216, 546274, 546319, 546320, 546321, 546324, 546325, 544360, 544364, A61K 31445, A61K 3155, C07D40506, C07D40514
Patent
active
052311040
ABSTRACT:
A series of novel 1-(phenethyl) and 1-(2-heteroarylethyl)-3-substituted piperidine derivatives have been prepared, including their pharmaceutically acceptable salts and various novel key intermediates therefor. The 3-substituent present in these compounds is an unsubstituted or substituted diphenylmethoxy group or a diphenylmethoxy-derived group, while the 1-substituent is unsubstituted or substituted phenethyl or 1-(2-heteroarylethyl) wherein the heteroaryl moiety is thienyl, pyridyl or pyrazinyl. These compounds in the form of both their racemates and 3R-isomers, are useful in therapy as smooth muscle muscarinic receptor antagonists and therefore, are of value in the treatment diseases associated with altered motility and/or smooth muscle tone.
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Alker David
Cross Peter E.
Wallis Robert M.
Ginsburg Paul H.
Higel Floyd D.
Pfizer Inc.
Richardson Peter C.
Strassburger Philip C.
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