Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1979-02-05
1980-11-25
Waltz, Thomas A.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
564 86, 564192, 564196, 564212, 564213, 564219, 564221, 260349, 260465D, 424304, 424320, 424321, 424324, 560155, 560250, 424311, 424312, A61K 31165, A61K 3118, C07C10340
Patent
active
042358922
ABSTRACT:
Described are D-(threo)-1-aryl-2-acylamido-3-fluoro-1-propanols, methods for their preparation, and methods for their use as antibacterial agents.
Of particular interest are D-(threo)-1-p-nitrophenyl-2-dichloroacetamido-3-fluoro-1-propanol and D-(threo)-1-p-methylsulfonylphenyl-2-dichloroacetamido-3-fluoro-1-propanol and the corresponding 2-difluoroacetamido compounds which are the 3-fluoro-3-deoxy analogs of chloramphenicol, thiamphenicol, difluoroacetyl analog of chloramphenicol, and of fluorthiamphenicol, respectively, and which are active both against organisms sensitive to and resistant to the parent amphenicol antibiotics.
Other particularly valuable antibacterial agents include the corresponding 2-(chlorofluoroacetamido)-, 2-dichlorodeuterioacetamido, 2-difluorodeuterioacetamido-, and the 2-(chlorofluorodeuterioacetamido)- derivatives of the foregoing 3-fluoro-3-deoxy amphenicols.
REFERENCES:
patent: 2717268 (1955-09-01), Rebstock et al.
patent: 2727070 (1955-12-01), Jacob
patent: 2727071 (1955-12-01), Jacob et al.
patent: 2759927 (1956-08-01), Suter
patent: 2759970 (1956-08-01), Suter
patent: 2759971 (1956-08-01), Cutler et al.
patent: 2759972 (1956-08-01), Suter
patent: 2776992 (1957-01-01), Gregory
patent: 2876261 (1959-03-01), Jacob
patent: 3012073 (1961-12-01), Gregory
Kono et al., Jap. J. Microbiol., 15 (3), 219-227 (1971).
Hahn, Antibiotics, p. 308 (1967).
Hahn et al., Antibiotics and Chemotherapy, 6, No. 9, p. 531 (1956).
Cima et al., Il Farmeco, Ed. Sc. 12, No. 6, 535 (1957).
Mitsuhasi et al., Jap. J. Microbiol, 13, No. 2, 177-180 (1969).
King Mary S.
Schering Corporation, Patent Dept.
Waltz Thomas A.
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