1 And 2-substituted analogues of certain prostaglandins

Details 1 And 2-substituted analogues of certain prostaglandins 1 And 2-substituted analogues of certain prostaglandins

1978-06-05

1979-10-16

Sutto, Anton H.

Chemistry of carbon compounds

Dipeptides, e.g., aspartame, anserine, carnosine, etc.

260563R, 2605676M, 260586R, 260607AL, 260609E, 260609D, 260953, 260609F, 260607R, 542429, 424214, 424217, 42424857, 424320, 424325, 421329, 421331, 421337, 421343, 544173, A01N 936, C07F 940

Patent

active

041713311

ABSTRACT:
Disclosed are trans 1 & 2-di(loweralkyl)phosphono; 1 & 2-chloro, bromo and iodo; 1 & 2-thio and 1 & 2-amino analogues of E.sub.1, A.sub.1, F.sub.1.alpha., F.sub.1.beta., 11 deoxy E.sub.1, 11 deoxy F.sub.1.beta., and 11 deoxy F.sub.1.alpha. prostaglandins.
The prostaglandins of this invention are variously useful as antithrombic agents, bronchodilators such as in the treatment of asthma, inhibitors of gastric secretion and as antihypertensive agents. Certain of the prostaglandins disclosed herein are useful as precursors for prostaglandins having one or more of the foregoing utilities.

REFERENCES:
patent: 3632627 (1972-01-01), Gordon et al.
patent: 4105792 (1978-08-01), Skuballa et al.
Claim 1 of U.S. 4,081,478, Mar. 28, 1978 OG.
Claim 1 of U.S. 4,085,139, Apr. 18, 1978 OG.

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