1-(aminophenyl)-2-aminopropanone derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

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514212, 5142275, 5142388, 514255, 514331, 514428, 544 59, 544165, 544392, 544399, 544404, 544410, 546235, 548566, 564342, 564343, 564345, A61K 31135, C07C22522

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active

049803778

ABSTRACT:
The present invention relates to the preparation of new 1-(aminophenyl)-2-aminopropanone derivatives of the general formula: ##STR1## in which X is NH.sub.2, Y is H or a halogen atom, Z is H or a halogen atom, R.sub.1 is C.sub.1 -C.sub.4 alkyl or C.sub.3 -C.sub.6 cycloalkyl and R.sub.2 is H or C.sub.1 -C.sub.4 alkyl, or R.sub.1 and R.sub.2, taken together, can form, with the nitrogen atom to which they are bonded, a heterocyclic group selected from the group consisting of the pyrrolidino, morpholino, thiomorpholino, piperidino, hexamethyleneimino, piperazino, 4-methyl-piperazino, 4-(.beta.-hydroxyethyl)piperzaino, 4-phenylpiperazino and 4-(p-chlorophenyl)piperazino groups, and addition salts thereof.
These new derivatives are useful as pharmaceuticals. They are obtained by deacetylation of the corresponding acetylated products.

REFERENCES:
patent: 2128255 (1938-08-01), Krzikalla et al.
patent: 3536712 (1970-10-01), Keck et al.
patent: 3772275 (1973-11-01), Hernestam et al.
patent: 3819706 (1974-06-01), Mehta
patent: 4119710 (1978-10-01), Engelhardt et al.
patent: 4282206 (1981-08-01), Warner, Jr. et al.
patent: 4393078 (1983-07-01), Peck
Chemical Abstracts, vol. 40, No. 7, Apr. 10, 1946.

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