1-[(Aminooxy)-methyl]-6-substituted-4H-s-triazolo[4,3-a][1,4] be

Details 1-[(Aminooxy)-methyl]-6-substituted-4H-s-triazolo[4,3-a][1,4] be 1-[(Aminooxy)-methyl]-6-substituted-4H-s-triazolo[4,3-a][1,4] be

1976-03-15

1977-02-22

Randolph, John D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424263, 424269, 2602948B, 2602948C, 2602948R, 260296B, 260308R, C07D48704

Patent

active

040091759

ABSTRACT:
Compounds of the formula: ##STR1## wherein R'o and R"o are hydrogen or alkyl of 1 to 3 carbon atoms, inclusive; R.sub.1 is hydrogen, fluoro, chloro, bromo, nitro, trifluoromethyl, or alkylthio in which the alkyl moiety is of 1 to 3 carbon atoms, inclusive; R.sub.2 is phenyl, o-chlorophenyl, 0-fluorophenyl, 2,6-difluorophenyl and 2-pyridyl are prepared by multistep reactions from compounds of formula I: ##STR2## wherein R.sub.1 and R.sub.2 are defined as above and X is chlorine or bromine.
Compounds of formula III, intermediates in the preparation thereof, Schiff's bases of compounds IIIA (III in which R'o and R"o are hydrogen), and the pharmacologically acceptable acid addition salts are useful in birds and mammals, including man, as sedatives, antianxiety, antidepressant, anticonvulsive, and muscular relaxing agents.

REFERENCES:
patent: 3681343 (1972-08-01), Hester
patent: 3842090 (1974-10-01), Gall
patent: 3912753 (1975-10-01), Hester
patent: 3966943 (1976-06-01), Hester

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