1-Aminomethyl-2,2-diaryl-cyclopropane carboxamides

Details 1-Aminomethyl-2,2-diaryl-cyclopropane carboxamides 1-Aminomethyl-2,2-diaryl-cyclopropane carboxamides

1973-11-19

1976-11-02

Hines, Robert V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260239BF, 260243B, 2602472A, 2602477Z, 260268R, 260268CN, 26029376, 26032643, 2603265M, 26032662, 26032685, 260465E, 2605011, 26050115, 26050117, 26050118, 26050119, 26050121, 260558A, 260559A, 424244, 424246, 424248, 424250, 424267, 424274, 424304, 424324, 26029375, C07C10112, C07C10114, C07C10116, C07D30762

Patent

active

039897222

ABSTRACT:
The invention relates to 1-aminomethyl-2,2-diaryl cyclopropane carboxamides of the general formula ##SPC1##
In which R represents the hydrogen atom, a halogen atom or a lower alkyl group or a lower alkoxy group; R.sub.1 and R.sub.2 which may be the same or different each represent a hydrogen atom, a lower alkyl group, an aryl group or an aralkyl group, in addition to which R.sub.1 and R.sub.2 together can form with the nitrogen atom to which they are attached a heterocyclic group with 5 to 7 peaks capable of containing a second hetero atom and capable of being substituted, and to their addition salts as new industrial products.
These products are suitable for therapeutic application, in particular in the treatment of Parkinson's disease.

REFERENCES:
patent: 3098076 (1963-07-01), Baltzly et al.
patent: 3419604 (1968-12-01), Kaiser et al.
patent: 3562276 (1971-02-01), Teotino et al.
patent: 3574742 (1971-04-01), Lapidus et al.
patent: 3646146 (1972-02-01), Teotino et al.
"Cyclopropanes . . . ," Walborksy et al., CA 50:8472 i (1956).
"Esters of 2,2-diphenylcyclopropanecarboxylic acids," Cognac CA 79:18432h (1973).
The Chemistry of Amides, Zabicky, ed., Interscience (1970), pp. 119, 525.

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