1-Aminoalkane-1,1-diphosphonic acids and their salts

Details 1-Aminoalkane-1,1-diphosphonic acids and their salts 1-Aminoalkane-1,1-diphosphonic acids and their salts

1974-05-31

1976-09-07

Weinberger, Lorraine A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26029351, C07D29504

Patent

active

039793850

ABSTRACT:
A process for the production of 1-aminoalkane-1,1-diphosphonates of the formula ##SPC1##
Wherein R.sub.1 is a member selected from the group consisting of hydrogen, lower alkyl and phenyl, R.sub.2 and R.sub. 3 are members selected from the group consisting of hydrogen, alkyl having 1 to 22 carbon atoms, cycloalkyl having 5 to 6 carbon atoms, phenyl, alkylphenyl having 7 to 18 carbon atoms, phenylalkyl having 7 to 18 carbon atoms and together with the nitrogen atom, piperidino, pyrrolidino and morpholino, and X is a member selected from the group consisting of hydrogen, alkali metal, ammonium, pyridinium, guanidinium and mono-, di-, and tri-lower-alkanol-ammonium with the proviso that at least one of R.sub.1, R.sub.2 and R.sub.3 is other than hydrogen, which consists essentially in reacting a phosphorus trihalide selected from the group consisting of phosphosus trichloride and phosphorus tribromide with a monocarboxylic acid amide of the formula ##SPC2## wherein the molecular weight of said carboxylic acid amide is over 46 and R.sub.1, R.sub.2 and R.sub. 3 have the above assigned meanings, at a temperature of from 0.degree. to 75.degree.C, subjecting the resultant reaction product to hydrolysis, and recovering said 1-aminoalkane-1,1-diphosphonates. The 1-aminoalkane-1,1-diphosphonates, some of which are novel, are capable of forming complexes with heavy metals.

REFERENCES:
patent: 3488419 (1970-01-01), McCune et al.
patent: 3617343 (1971-11-01), Kandler et al.
patent: 3668138 (1972-06-01), Hoover et al.
patent: 3792084 (1974-02-01), Quinlan
patent: 3846482 (1974-11-01), Kerst

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